In summary, our results demonstrate that 14 lncRNAs (HAGLR, ADAMTS9-AS2, LINC00261, MCM3AP-AS1, TP53TG1, C14orf132, LINC00968, LINC00312, TP73-AS1, LOC344887, LINC00673, SOX2-OT, AFAP1-AS1, and LOC730101) had the potential to separate cancerous from non-cancerous lung tissue as well as LUAD from LUSC in the early stages of NSCLC. The gene discussed is AFAP1; the disease is non-small cell lung carcinoma.