However, in a more complex task of distinguishing NSCLC subtypes, a gradient boosting decision tree classifier (GBDT) was used to create the final simplified regression model based on four lncRNAs (AFAP1-AS1, SOX2-OT, LINC00261, and LINC00673) that was found to be a robust predictor of NSCLC subtype (AUC value of 0.88 ± 0.07). This evidence concerns the gene SOX2 and non-small cell lung carcinoma.