When analyzing LUSC tumor tissue vs. normal lung tissue, we observed a significant decrease in expression of 10 out of 14 lncRNAs (HAGLR, ADAMTS9-AS2, LINC00261, MCM3AP-AS1, TP53TG1, C14orf132, LINC00968, LINC00312, TP73-AS1, AFAP1-AS1); 3 lncRNAs (LOC344887, SOX2-OT, LINC00673) showed higher expression and lncRNA LOC730101 was statistically insignificant. Here, AFAP1 is linked to neoplasm.