More recently, in silico screens have identified a number of natural and synthetic molecules such as 15-Keto prostaglandin E2, Osthole and Betulinic acid have the capacity to inhibit STAT3 activity and, as a consequence, suppress breast cancer cell growth; however, these studies have not progressed beyond the in vitro assay phase [119,120,121]. The gene discussed is STAT3; the disease is breast carcinoma.