Although IL-6R and IL-11R are expressed in specific cell types, gp130 is ubiquitously expressed allowing for the activation of intracellular STAT3 signaling in cells with limited or no IL-6R and IL-11R expression, via sIL-6R and sIL-11R by tumor infiltrating neutrophils, monocytes and T-cells [16,21,22,23]. The gene discussed is STAT3; the disease is neoplasm.