For example, the application of natural tissue-specific promoters, like the albumin promoter combined with alpha-fetoprotein (AFP) [11] or telomerase reverse transcriptase (TERT) [19] promoter, restrict vector genome expression to the oncogene-overexpressing tumor cells, while the use of optimized synthetic promoters finetunes the expression efficiency [69]. The gene discussed is TERT; the disease is neoplasm.