Third, reactivation of certain viral pathogens (herpes and retro viruses) that stay in latency after initial infection, is induced by bacterial toxins, (CDT), metabolites (e.g., butylate) as well host secretory molecules in response to bacterial infection (GM-CSF, INFγ, TGFβ and ROS). The gene discussed is TGFB1; the disease is bacterial infectious disease.