Somatic mutations in AT-rich interaction domain 1A (ARID1A), which is a subunit of the SWItch/sucrose non-fermentable (SWI/SNF) chromatin remodelling complex and is thought to have a tumour suppression role by regulating chromatin structure and gene expression, have been detected frequently in both EBV- and H. pylori-associated GC [113,149,150]. This evidence concerns the gene ARID1A and neoplasm.