AFP and hepatocellular carcinoma: In this context, the Mayo clinic reported that the hazard ratio of HCC recurrence after liver transplantation was 5.2 when both AFP ≥ 250 ng/mL and PIVKA-II ≥ 7.5 ng/mL were considered together, compared to 3.5 and 2.8 when applying PIVKA-II ≥ 7.5 ng/mL alone and AFP ≥ 250 ng/mL alone, respectively [47].