Ultimately, the 5-5-500 criteria (tumor ≤ 5 cm in diameter, tumor number ≤ 5, and AFP ≤ 500 ng/mL) were established, with a 5-year recurrence rate of 7.3% (with a 95% confidence interval at 5.2–9.3) and a 5-year survival rate over 70% [26]. The gene discussed is AFP; the disease is neoplasm.