In addition to reactive activation of HIF-1, constitutive activation of HIF-1α by loss-of-function mutation of the VHL gene is the causative mutation of von Hippel–Lindau disease, a familial cancer syndrome characterized by renal cell carcinoma, pheochromocytoma, and hemangioblastoma (central nervous system and retina) [29]. The gene discussed is HIF1A; the disease is hereditary pheochromocytoma-paraganglioma.