The effect of new ciprofloxacin derivatives 4, 5, 8 and * free ciprofloxacin on early or late apoptosis in studied cancer (LNCaP and DU145) and normal RWPE-1 cell lines detected with Annexin V-FITC/7-ADD by flow cytometry a % of cells in early apoptotic state; b % of cells in late apoptotic state. This evidence concerns the gene ANXA5 and cancer.