Specifically, TGFBI, which encodes an RGD-containing protein that binds to type I, II, and IV collagens that are involved in modulating cell adhesion [38], was previously shown to be frequently methylated in ovarian cancer, and this could be leveraged as an epigenetic biomarker for discriminating ovarian cancer from non-cancer or borderline tumors [39]. Here, TGFBI is linked to ovarian carcinoma.