Moreover, 4βHWE dramatically inhibited tumor growth in HCT116 xenografts by promoting β-catenin degradation and downregulating protein levels of Axin2, c-Myc, and Cyclin D1 in mice treated with 5 mg/kg and 10 mg/kg/day for 14 days, suggesting its potential use as an antitumor agent that targets the Wnt/β-catenin signaling pathway [126]. The gene discussed is AXIN2; the disease is neoplasm.