Mutations within the PI3K/AKT/mTOR and RAS/RAF/MEK/ERK kinase signaling pathways are characteristic of the low-grade serous (LGSOC), mucinous (MOC), endometrioid (ENOC) and clear cell (CCOC) ovarian cancer subtypes [4,5,6,7]. The gene discussed is PIK3CA; the disease is ovarian cancer.