KRAS and lung adenocarcinoma: Although KRASG12C allele-specific drugs have greatly improved the clinical outlook for patients with KRASG12C tumors, particularly lung adenocarcinomas, in which the KRASG12C mutant is most prevalent compared with other KRAS mutations, inevitable challenges, such as intrinsic and acquired drug resistance, must be overcome to maximize the efficacy of KRASG12C inhibitor therapy.