All observed somatic mutations and short insertion/deletions are shown in Supplementary Figure S1, and those previously associated with cancer are shown in Figure 2B. The mutated genes and their mutation frequency were similar to those reported by TCGA, except for MSH6 and KMT2B genes, which showed reduced frequency in our series (26% and 13% in TCGA vs. 2.7% and 6% in our series, respectively). Here, MSH6 is linked to cancer.