The prognostic significance of MYC/MYCN amplification and histology is likely to be relevant only in the context of molecular subgrouping (e.g., MYC amplification in Group 3 tumours; MYCN amplification in SHH but not Group 4 tumours); therefore, clearer risk groups may become apparent as these refined prognostic associations are validated [5,42]. The gene discussed is MYCN; the disease is neoplasm.