Moreover, since accumulation of neutrophils in tumor-bearing mice modifies TME by secretion of factors that promote angiogenesis and increase tumor cell migration [33,42,43], the significant decrease of neutrophils in Rab27a-overexpressing tumor-bearing mice in this study may be another plausible explanation for the unexpected growth inhibition of Rab27a-overexpressing tumors. The gene discussed is RAB27A; the disease is neoplasm.