Consistent with previous findings that FAK and mitogen-activated protein kinase (MAPK) signaling play essential roles in cancer cell proliferation and metastasis [16,17], FAK, JNK, p38, and ERK1/2 phosphorylation was significantly increased by serum stimulation in both cells, and BHMPS treatment markedly inhibited the phosphorylation of these molecules, especially FAK and JNK (Figure 2B). Here, WNK2 is linked to cancer.