Since then, we have synthesized 15 BMD-11 derivatives and selected (E)-N-benzyl-6-(2-(3,4-dihydroxy benzylidene)hydrazinyl)-N-methylpyridine-3-sulfonamide (BHMPS), a new Rab27a-targeting synthetic compound that inhibits migration and invasion by downregulating ECM marker levels in A375 melanoma and MDA-MB-231 breast cancer cells [14]. This evidence concerns the gene RAB27A and breast carcinoma.