Figure 14A depicts DU145 cell growth data derived from cultures with 2 versus 10% FBS and with or without IGF-1-activation. The IGF-1-concentration did not influence integrin dependent alterations of DU145 chemotaxis, as shown in Figure 14B. Adhesion of DU145 cells to collagen and fibronectin in the presence of β1 function blocking antibodies was similarly blocked, whether tumor cells were grown in 2 or 10% FBS (Figure 14C). Here, FN1 is linked to neoplasm.