Using human androgen-independent prostate cancer cell lines (DU-145, PC3) as well as androgen-sensitive LNCaP and VCaP cells, the present study was designed to evaluate how IGF-1 is involved in integrin driven regulation of tumor cell adhesion and migration and, conversely, whether Akt/mTOR signaling activated by IGF-1 is involved in integrin driven regulation of tumor growth. The gene discussed is AKT1; the disease is Familial prostate cancer.