Type 1 collagen overexpression in tumor tissues has been implicated in the promotion of tumor growth, epithelial to mesenchymal transition (EMT), distant metastasis and increased stemness properties of CRC cells, through integrin α2β1 and the activation of PI3K/AKT/Snail and WNT/PCP signaling pathways [54,55,56]. Here, AKT1 is linked to colorectal carcinoma.