Remarkably, all analyzed signatures showed a significant negative correlation with CDK5RAP3 (Figure 4B), specially for triple negative breast cancer; that is, low expression of CDK5RAP3 was associated with relatively higher expression of the defined signatures, which, in turn, further endorses a functional link between CDK5RAP3 downregulation and chemoresistance. Here, CDK5RAP3 is linked to triple-negative breast carcinoma.