Combined results of the iCOGS and Oncoarray studies identified potential associations with cancer risk in these settings (minor allele frequency (MAF) > 0.01, p values < 10−3, see supplementary results and methods): BRCA1 mutation carriers, breast cancer risk, imputed rs536194633 HR = 0.90; and ovarian cancer risk, genotyped rs2905855 HR = 1.07, imputed rs201764131 HR = 0.91, and imputed rs6503964 HR = 0.93; BRCA2 mutation carriers, breast cancer risk, imputed rs77563750 HR = 1.11 and rs17617360 HR = 0.90. The gene discussed is BRCA1; the disease is breast carcinoma.