Moreover, ERK5 ablation in malignant mesothelioma cells is accompanied by a significant reduction in tumor size as a result of the downregulation of critical angiogenesis-related (IL-8, VEGF) and proinflammatory (RANTES/CCL5, MCP-1/CCL2) cytokines [81]. The gene discussed is CCL2; the disease is mesothelioma.