Doubly mutant PCa tissues for the Phosphatase and tensin homolog (Pten) and ERK5 exhibited a significant upregulation of lymphocyte-recruiting chemokines (Ccl5 and Cxcl10), as well as an increase in CD4+ T-cell infiltrate in the tumor stroma upon ERK5 ablation [169]. The gene discussed is PTEN; the disease is posterior cortical atrophy.