As a matter of fact, the downregulation of miR-143 usually results in a significant overexpression of ERK5, as in the case of different types of malignancies such as prostate cancer (PCa) [64,65], bladder cancer [66], BC [67,68], esophageal squamous cell carcinoma [69], nasopharyngeal carcinoma [70], acute myeloid leukemia [71], T-cell leukemia Jurkat cells [72], and B-cell malignancies [73]. Here, MAPK7 is linked to breast cancer.