SLC2A1 and malignant colon neoplasm: We next examined effect of GLUT1 inhibitor BAY-876 on selenite-induced cytotoxicity of HCT116 cells and results demonstrated that an enhanced cytotoxicity was achieved by all the combinations of selenite and BAY-876, further supporting the sensitization effect of glucose deprivation on selenite-induced cytotoxic effect against HCT116 colon cancer cells (Figure 1C).