BIN1 and neoplasm: Among the decreased transcripts, we validated (1) BIN1, which is a potential tumor suppressor [58] and is related to the GO-term “endosome to lysosome transport” (GO:000833), (2) PLAC8, that facilitates fusion of autophagosome and lysosomes [59] and (3) NPRL3, which is a lysosomal protein and part of the process “regulation of autophagosome assembly” (GO:2000785).