The current study is a follow-up on this work and we now demonstrate that activated STAT3 significantly increases the sensitivity towards these ACD-inducing drugs, with STAT3-proficient GBM cells showing an increased LMP-mediated leakage of lysosomal content such as cathepsins into the cytosol in comparison to STAT3-depleted cells. The gene discussed is STAT3; the disease is glioblastoma.