In this current study, we report that MYXV armed with murine LIGHT (TNF Superfamily member 14: TNFSF14) is also a positive hit in the K7M2-luc lung metastatic osteosarcoma model but possesses even more potent anti-cancer activities against advanced later-stage disease than vMyx-hTNF. Here, TNFSF14 is linked to cancer.