Given the unknown function of ETV6 in mature B-cell lymphomas and our results suggesting that high ETV6 expression may be relevant for the pathogenesis of highly aggressive DLBCL cases, we performed knock-down (KD) experiments in numerous cell lines expressing significant levels of ETV6, such as OCI-Ly3, RIVA, U2932 (all ABC-type), OCI-Ly19 (GCB-type) and RAJI (BL). This evidence concerns the gene CD8B and B-cell non-Hodgkin lymphoma.