Meanwhile, the study also found that m6A modification could exert oncogenic effects via elevating the translation level of related mRNAs [e.g., c-MYC, B-cell lymphoma/leukemia-2 (BCL2), phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene, etc.] in AML cells, thus further suggesting that METTL3 can act as an oncogenic factor in myeloid malignancies, which is an important reference value for clinical treatment. This evidence concerns the gene METTL3 and acute myeloid leukemia.