METTL3 and acute myeloid leukemia: In 2017, Vu et al. [114] found that METTL3 is highly expressed in AML cells and can promote AML cell proliferation, inhibit cell differentiation, and ultimately play an oncogenic role in AML through mediating m6A methylation modification; downregulation of METTL3 gene can induce the differentiation and apoptosis of AML cells by increasing the phosphorylation level of phosphate protein kinase B (PKB/AKT), but not apoptosis in normal hematopoietic cells.