RUNX1 and acute lymphoblastic leukemia: Using real-time qPCR (RT-qPCR), Sun et al. [118] detected that the expression levels of METTL3 and METTL14 are decreased in ETV6/RUNX1-positive P-ALL, indicating a possible role in the pathogenesis and progression of E/R-positive P-ALL, and thus laying the groundwork for specific treatments targeting patients with possible E/R-positive relapses.