Weng et al. [102] showed that METTL14 is also highly expressed in AML cells and can play a critical role in the pathogenesis of both normal myelopoiesis and AML via mediating m6A methylation modifications that block the differentiation of normal myeloid cells and promote malignant hematopoiesis. This evidence concerns the gene METTL14 and acute myeloid leukemia.