TGFB1 and neoplasm: From a functional point of view, there are two spectra of tumor-associated macrophage (TAM) in tumors: (i) M2-like TAMs, which have anti-inflammatory and regenerative activities that arise from cytokines derived from TH2 lymphocytes such as TGF-β, IL4, IL10, and IL13; and (ii) M1-like TAMs, which have inflammatory and antitumor activity and are produced in response to the INFɤ produced by TH1 lymphocytes.