PRMT1 and PRMT5 regulate the EGFR signaling pathway by methylating EGFR (in colorectal and TNBC cells) [20,21,22], or by methylating histones on the EGFR promoter (in glioblastoma or colorectal cells) [23,24] to regulate its transcription. The gene discussed is PRMT1; the disease is glioblastoma.