EGFR and colorectal cancer: PRMT1 has been previously observed to modulate EGFR signaling by two mechanisms: (i) by methylating histone H4 (H4R3me2a) on its promoter in colorectal cancer (CRC) [23] and glioblastoma cells [24] and (ii) by methylating EGFR in CRC and TNBC cells [20,21].