Additionally, tissue samples of cSCCs from patients with recessive dystrophic epidermolysis bullosa (RDEB), a rare hereditary blistering disorder caused by germline mutations in the COL7A1 gene, which codes for type VII collagen, i.e., (RDEBSCC, n = 16), were examined as an example of an aggressive form of cSCC. This evidence concerns the gene COL7A1 and recessive dystrophic epidermolysis bullosa.