In addition, elevated production of FD protein by four out of eight cSCC cell lines was noted by Western blotting, and the levels of FD protein were highest in two metastatic cSCC cell lines (UT-SCC-115 and-7) and in two primary cSCC cell lines (UT-SCC-91 and-12A). The gene discussed is ELP1; the disease is skin squamous cell carcinoma.