Hypermethylation of three CpGs (cg13261825, cg03260566 and cg01663016) in SLIT1, SLIT2 and SLIT3 genes was found at a higher prevalence in adenocarcinoma than in squamous cell carcinoma, although the difference was not statistically significant (Figure 1E). This evidence concerns the gene SLIT3 and adenocarcinoma.