Recent analysis from TCGA categorised tumours of mixed ductal and lobular histology into ILC-like, mainly harbouring CDH1 mutations and alterations more commonly seen in pure ILCs (such as FOXA1 and TBX3 mutations) and IDC-like (lacking CDH1 mutations and enrichment of mutations more commonly seen in pure IDC) [6]. The gene discussed is TBX3; the disease is neoplasm.