SOX2 and breast cancer: Even though the total number of THC was not affected by PBA or SB, we observed that the CSC features of these cells were reduced by these treatments in macrophage–BC cell line co-cultures, which is indicated by a significant decrease in pluripotency markers such as MYC, NANOG and SOX2 as well as miRNAs associated with cancer stemness such as miR-21 and miR-302.