By releasing an extracellular regulator, galectin-3, tumor cells are capable of blocking interferon gamma (IFN-γ) in the TME followed by impeding chemokines CXCL9, CXCL10, and CXCL11 leading to obstructed T-cell recruitment into the tumor bed [184] (Table 1). The gene discussed is IFNG; the disease is neoplasm.