Bagati et al. demonstrate, via the integrin αvβ6–TGF-β–SOX4 signaling pathway, SOX4 expression is upregulated by the integrin αvβ6 receptor on the surface of TNBC tumor cells thereby changing transforming growth factor (TGF)-β from a latent precursor to an active form [45] (Figure 1A; Table 1). Here, SOX4 is linked to neoplasm.