Transcriptome analysis of SF3B1WT and SR3B1MUT tumors from CLL, UVM, and breast cancer patients allowed the identification of splicing alterations associated with SF3B1 hotspot mutations and revealed that SF3B1MUT stimulates the usage of cryptic 3′ splice sites by recognizing a cryptic BPS [34,35,36]. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.