Fenofibrate, a PPARα agonist, and FH535, a Wnt inhibitor, resulted in dose-dependent impairment of cellular proliferation in HPV16+ UMSCC47 and UPCI:SCC090 HNSCC cell lines; complete ablation of cell growth was observed at 100 μM and 30 μM doses of fenofibrate and FH535, respectively (Figure 5A and Figure S1). This evidence concerns the gene PPARA and head and neck squamous cell carcinoma.