In particular, these focal amplifications were found to display inter-or intra-chromosomal translocations with significant breakpoint clustering, similar to what is seen in human MM, particularly oral MM, which presents inter-and intra-chromosomal translocations between or within HSA 5 (TERT) and HSA 12 (CDK4) [14,16]. Here, CDK4 is linked to Miyoshi myopathy.