In the Cancer Genome Atlas, we found one case of acral melanoma (TCGA-ER-A19T-01) harboring a strong focal amplification on chromosome 15 (orthologous to canine chromosome 30) encompassing the candidate oncogenes SPPL2A, USP8, TRPM7, and GABPB1. The gene discussed is GABPB1; the disease is acral lentiginous melanoma.