In the Cancer Genome Atlas, we found one case of acral melanoma (TCGA-ER-A19T-01) harboring a strong focal amplification on chromosome 15 (orthologous to canine chromosome 30) encompassing the candidate oncogenes SPPL2A, USP8, TRPM7, and GABPB1. This evidence concerns the gene SPPL2A and acral lentiginous melanoma.