Our results reveal that CAPE blocks the expression of the MALT1 gene to decrease the cell proliferation, invasion, and tumor growth of prostate carcinoma cells via the p53 and NF-κB signaling pathways, and they further verify that CAPE is an effective antitumor agent for human androgen-dependent and -independent prostate carcinoma cells by inhibiting MALT1 expression in vitro and in vivo. This evidence concerns the gene NFKB1 and prostate carcinoma.