RNA encodes four tumor-associated antigens (TAAs)—New York oesophageal squamous cell carcinoma 1 (NY-ESO-1), melanoma-associated antigen A3 (MAGE-A3), tyrosinase, and trans-membrane phosphatase with tensin homology (TPTE)—that present limited normal tissue expression, elevated immunogenicity, and prevalence in melanoma. This evidence concerns the gene TYR and melanoma.