FOLH1 and pachyonychia congenita: Based on a 5-point scale, this framework categorizes lesions based on their likelihood of PC involvement, with PSMA-RADS-1 being certainly benign, whereas PC is almost certainly present in a PSMA-RADS-5 lesion [10,11,12], thereby allowing for lesion-level characterization that may be helpful in planning focal therapy for limited volume disease and defining work-up strategies for indeterminate findings.