CYP19A1 and endometrial cancer: Notably, since the increased expression of aromatase in type I endometrial cancer has been associated with the expression of cyclo-oxygenase (COX)-2, the inhibition of prostaglandin 2, i.e., by aspirin or COX-2 inhibitors, may result in reduced estrogen biosynthesis, and could provide a potential preventive/therapeutic target.