However, the effects of obesity on endometrial cancer have been shown to be significant, even after adjusting for sex hormones [39], thereby suggesting the role of other adiposity-related pathways, which include insulin- and adipokine-mediated effects, the secretion of proinflammatory mediators from adipose tissue, and adiposity-associated oxidative stress [40,41]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.