STAT3 and neoplasm: Consistent with this, we observe here that both the antisense-mediated reduction of Stat3 expression in shStat3 mice and the antagomir-based suppression of miR-21 restore Pten expression [65], and the phenotypic consequences on these genetic manipulations on the tumor burden of Gp130F/F mice was opposite to that observed following the genetic ablation of Pten in these mice.