ACTA2 and adenoma: Indeed, in addition to the reduced Acta2 staining observed in the tumors of miR-21 antagomir-treated mice (Figure 6A), we also noted reduced immunohistochemical signals for the two extracellular matrix components fibronectin and fibroblast activation protein alpha (FAP) (Figure 7B) when compared to adenomas extracted from scrambled antagomir-treated mice.