The ChIP analysis of tumor DNA from Gp130F/F mice, prepared 60 min after a single IL-11 administration to activate Stat3 signaling, identified two potential Stat3 binding peaks at −38 kb and ~3.5 kb upstream of the miR-21 promoter and within introns of the overlapping transmembrane protein 49 (TMEM49) gene (Figure 2C). This evidence concerns the gene IL11 and neoplasm.