Other ion channels such as the Ca2+ -activated chloride channel TMEM16A which modulates mucin secretion and airway smooth muscle contraction, and is upregulated in asthmatic patients [2,5] or several TRP channels such as TRPC6, TRPV1, TRPV4, or TRPM6 have been demonstrated to be involved in pathways associated with asthma, CF, emphysema/COPD, lung fibrosis, or edema formation [6]. This evidence concerns the gene MUC5AC and chronic obstructive pulmonary disease.