In both Trpml3−/− mouse models elastance (captures the elastic rigidity or the stiffness of the lungs) was reduced and compliance (captures the ease with which the lungs can be extended, i.e., lung’s ability to stretch and expand) was increased, major characteristics of emphysema, further exacerbating upon instillation of porcine pancreatic elastase or when exposed to tobacco smoke. The gene discussed is MCOLN3; the disease is pulmonary emphysema.