Other lung function parameters such as tissue elasticity, inspiratory capacity, quasistatic compliance, or total lung capacity were also changed in an emphysema-like manner and the quantitative histological analysis under basal conditions and after elastase/tobacco smoke treatment revealed increased airspace enlargements, which were more pronounced in Trpml3−/− mice compared to WT mice. The gene discussed is MCOLN3; the disease is pulmonary emphysema.