Scruggs et al. [46] further demonstrated that this upregulation of KCNMB1 contributes to increased BK channel activity in IPF fibroblasts, fostering differentiation of fibroblasts into myofibroblasts, a critical step in the development of fibrotic disorders such as IPF. The gene discussed is KCNMA1; the disease is idiopathic pulmonary fibrosis.