TRPC6 and pulmonary emphysema: Thus, e.g., TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema [7] and lungs from mice lacking TRPC6 are protected from lung ischaemia-reperfusion-induced oedema (LIRE) [8], while magnesium deficiency in TRPM6 results in severe emphysema [9].