EPAS1 and Miyoshi myopathy: In MM, various studies have shown that neoplastic plasma cells from newly diagnosed MM patients exhibit an increase in HIF1α and HIF2α regulated pathways compared to cells isolated from healthy donors [21,22,27] and that inhibition of HIF1α might provide a strategy to prevent hypoxia-induced adaptations in malignant plasma cells [28,29,30,31,32].