CCL2 and neoplasm: As senescent cells may express the senescence-associated secretory phenotype (SASP) to induce and maintain the senescence phenotype in normal surrounding cells to properly burst tumor progression, we moved to test the senotherapeutic effect of LAV-BPIFB4 on the secretion of main SASP factors which included cytokines (IL-6, IL-8 and IL-1β) and other factors such as monocyte chemotactic protein 1 (MCP1).