Although the precise function of ALKBH5, FTO and METTL3 in pancreatic β cells remains unknown, as well as their specific function and their target RNAs in the cytoplasm or nucleus, it is tempting to speculate that these enzymes may play a fundamental role in pancreatic β-cell function or identity, and, consequently, T2D physiopathology. This evidence concerns the gene ALKBH5 and type 2 diabetes mellitus.