Moreover, there is increasing evidence that CYP2E1 plays a significant role in obesity-associated nonalcoholic fatty liver disease (NAFLD), in particular by favoring the progression of simple fatty liver (i.e., steatosis) to nonalcoholic steatohepatitis (NASH) [2,3]. The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatotic liver disease.