INS and Alzheimer disease: Within Cluster I, we identified several potential targets (Figure 5f), including CG5214, a succinyltransferase that regulates post-translational modifications of proteins and is associated with aging [66,67], and the transcriptional coactivator spargel (srl), the Drosophila homolog of PGC-1αβ–a gene involved in mitochondrial homeostasis and Insulin-TOR signaling, which has been implicated in AD pathogenesis [68,69].