Independently, in the proteomic screening of lipocalin-2 (LCN2)-deficient cells, which exhibited an altered mitochondrial function and fatty liver disease, MCPH1 was identified as a strongly downregulated protein [118]; however, it is unclear if this observation relates to its possible function at mitochondria or is a result of tumorigenesis in these mice. This evidence concerns the gene LCN2 and fatty liver disease.