Analyzing the IF colocalization of LC3B/LAMP-1 as a hallmark of autophagy (autophagolysosomes) in PBMCs from SLE patients, we observed a significant reduction with respect to HDs at all of the timepoints, as shown in Figure 3A,B (* p = 0.029 t0 vs. t12; ** p = 0.008 t0 vs. HDs; * p = 0.011 t2 vs. HDs) and in Figure S1A,B (* p = 0.049 t0 vs. t12; * p = 0.021 t0 vs. HDs; * p = 0.012 t2 vs. t12; * p = 0.029 t2 vs. HDs). The gene discussed is MAP1LC3B; the disease is systemic lupus erythematosus.