Gene array (Figure 4B) followed by real-time PCR analysis of individual genes (Figure 4C) clearly showed that p40 mAb treatment markedly increased the expression of apoptosis-related genes such as cytochrome C, caspase 3, caspase 8, caspase 9, p53, BAD, BID, BAX, and BAK in tumor tissues of PDX mice. This evidence concerns the gene CYCS and neoplasm.