Meanwhile, it has been shown that spatial learning and memory impairment is caused by synaptic dysfunction both in human patients and different transgenic mouse models of AD, e.g., AppNL-G-F [12,13], Tg2576 [14], APP/PS1 [15], 5×FAD [16], and 3×Tg-AD [17]. This evidence concerns the gene APP and Alzheimer disease.