APP and Alzheimer disease: Consistently, after histopathological inspection, the elderly WT mice employed in this study show no signs of amyloidosis; furthermore, in these mice up to 16 months of age, the detection of iAβ is questionable: it appears to be present in some aged mice, with a pattern partly similar to that observed in young AD mice, but only with the less specific antibody (4G8) that also detects APP/βCTFs.