Characteristic markers, such as KRT5, 15 and 17, ITGA2, Sox4, Sox9, and CD24, are expressed at high levels, together with the AEC2 genes SFTPB and C. Genes involved in surfactant protein processing and secretion are also expressed in the IPF Lysopos population, although they do not reach the level of expression of the donor AEC2s, which correlates well with the low and intermediate levels of LysoTracker incorporation in this population. Here, SFTPB is linked to idiopathic pulmonary fibrosis.