In addition, two fundamental regulators of AEC2 fate had opposite patterns of expression: IPF Lysopos cells expressed markedly decreased levels of ETV5 (LFC =−3.42, LOG(p) = 2.32), but SOX9 (LFC = 3.25, LOG(p) = 8.93) was one of the top overexpressed genes in our data set (Figure 5D and Supplemental Figure S5C,D). This evidence concerns the gene SOX9 and idiopathic pulmonary fibrosis.